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No specific dose adjustment at standard doses

The Phase 3 OPTIONS study (536 subjects, 24 weeks) failed to show statistically significant weight loss compared to placebo

The thymalin peptide , a related thymic peptide, operates through similar but distinct mechanisms that may also have relevance to immune dysregulation conditions

Postural Tachycardia and Dizziness (POTS): By supporting the COMT enzyme's ability to clear excess adrenaline and supporting the autonomic nerves responsible for baroreceptor function, B12 may help stabilize heart rate upon standing and reduces the severity of hyperadrenergic adrenaline surges