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In some embodiments, the antioxidant or anti-apoptotic agent protects against drug-induced ototoxicity

Sirtuin-1 is the main deacetylase of PGC-1 ( PGC-1 could dock on NRF 1 and 2 to together drive the transcription and translation of the genes involving TCA cycle and OXPHOS systems, and then induce mitochondrial biogenesis

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Therefore, the FDA approval status of Cellgevity is different from that of prescription medications

The diet emphasizes consumption of nutrient-dense whole foods which contain nutrients known to be protective against glutamate excitotoxicity, including foods high in omega-3 fatty acids (98, 99) and important for reduction in glutamate excitotoxicity (100, 101)