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Forced expression of GSTP1 in control and HPV-16 E7-infected MCF-7 cells restored the ability of HPV-16 E7 to protect against UV-induced cell death ( p = 0.0046, **)

Instead, its effects on wakefulness appear to be a downstream consequence of its interaction with major neurotransmitter systems

J Biol Chem 1997;272:17269-75

Topical serums work at the skin surface and in the uppermost layers of the dermis, which means they address pigmentation locally rather than systemically