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They can have an opposite effect (most commonly) or parallel effect (note, this parallelism occurs with quite distinctive models, i.e., amphetamine-effect [70], miosis [91], atropine-mydriasis [91], huge magnesium over-dose [85], ischemic/reperfusion colitis [49], duodenal congestion lesions [251], cecum perforation [174])

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Gene expression modulation: GHK-Cu affects over 4,000 genes based on microarray studies

Journal of Medicinal Chemistry, 64(15), 11183-11194