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Using Mendelian randomization and UK Biobank data, researchers found that this biological response signature is causally associated with a significantly lower risk of Ischemic Heart Disease (OR = 0.87) and diabetes (OR = 0.66), cementing berberine's status as a powerful cardioprotective agent

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The compound is administered subcutaneously in the abdomen, thigh, or deltoid using an insulin syringe

The EF-hand domain consists of two regions of -helix linked by a short (usually 12 amino acids) loop region