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Interactions between resident immune cells in the CNS and peripheral immune cells through immune molecules render inflammation systemic, ultimately leading to the dysfunction of neuromuscular junctions, damage to motor neuron axons, and motor neuron death [255]

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However, this absorption method occurs only to a limited extent

doi: 10.3389/fphys.2021.717550 Received 31 May 2021 Accepted 19 July 2021 Published 19 August 2021 Volume 12 - 2021 Edited by Zhihong Yang, Universit de Fribourg, Switzerland Reviewed by Xiu-Fen Ming, Universit de Fribourg, Switzerland

Removal from Category 2 is a step, not a clearance