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4: prolonged and frequent withdrawal (30 s) accompanied by shaking, licking and/or vocalization ( 2.5.2 Hot plate test In this experiment, we assessed thermal hyperalgesia related to neuropathic pain in rats by measuring their paw withdrawal latency (PWL) using a hot plate apparatus (Harvard Apparatus, Holliston, MA)

Nevertheless, our findings in erythrocytes and previously published in SCD cardiac tissues 46 support that, in addition to inflammation suppression 23 and fetal globin induction 31,63,64 , DMF displays anti-oxidative and ferroptosis stress effects to alleviate SCD clinical severity, and therefore, might be pursued as a new treatment option

10.3390/toxins13040271 30 GarzaS.JamesG.ParkH

INNOSC Theranostics and Pharmacol Sci 2025;8:80-90

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