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"GABA B receptors"

B 2 , 1190 (2014)

Moderate physical activity strengthens the cardiovascular system, while excessive training leads to overuse injuries and systemic stress

Additionally, the evidence regarding long-term safety remains inadequate, particularly concerning chronic administration and effects on vulnerable populations such as elderly individuals, pregnant women, and those with severe psychiatric comorbidities

In addition, oxidative stress significantly accelerates the telomere shortening and ageing of chondrocytes, while ageing promotes the development of KOA, damages the regulation of redox of mitochondria in cartilage, and stimulates ROS production to further aggravate KOA