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Bennell, K

Dissociated hippocampal neurons were treated with H2O2 for 24hrs +/- HGF at sub-threshold concentrations 5ng/ml and or Dihexa at 2 different concentrations 10 "8 M and 10 "8 M

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Although there is no evidence of direct SIRT1 agonism, urolithin A is a well described mitophagy activator (63, 66, 67), contributing to improved mitochondrial efficiency and redox balance, which can indirectly improve SIRT1 expression and activity (68)

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