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A retrospective study looking at concomitant use of proton pump inhibitors (PPIs) alongside metformin in 614 people with type 2 diabetes in the US found a significant reduction in B12 levels of 34% in patients taking both medications, compared to controls taking either drug alone (Long et al, 2012)

Glutathione is a powerful antioxidant known as the master antioxidant, pivotal in alleviating oxidative stress and protecting individual cells and tissues from free radicals

Liu, D., et al., Collagen and gelatin

Health 3 , e16 (2016)

However, low expression levels of the three enzymes, specifically in beta cells of mice, have not been studied in detail