cigarette smoke perinuclear clustering mitochondria lung epithelial Organoids in Smoking Research: Current Advances and Future Promises A chronic whole cigarette smoke

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These compounds also elevate intracellular reactive oxygen species (ROS), exacerbating oxidative stress and further promoting adduct formation (Yan et al., 2023

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27 Studying CS exposure, researchers first found abnormal changes in mitochondrial morphology in primary airway epithelial cells derived from COPD patients, including crista defects, abnormal branches, and swollen and fragmented organelles