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Dihexa induces spinogenesis in cultured hippocampal neurons Actin-enriched spines increased in number in response to both dihexa (Figure 38B&D) and Nle'-AnglV (Figure 38C&D) following 5 days of treatment at 10 "12 M concentration that started on the 7 th day in vitro (DIV7) the results revealed a near 3-fold increase in the number of spines stimulated by dihexa and greater than 2-fold increase for Nle f -AngIV

Nat Rev Genet

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However, the existing body of research suggests that Dihexa could be a promising tool in the treatment of cognitive disorders and neurodegenerative diseases