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There is a theoretical case for using both in certain patients, targeting different physiological mechanisms simultaneously, though this approach is under evaluation and not yet standard of care

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A: B12 toxicity is extremely rare because excess amounts are eliminated through urine

Experimental injury, a surgical incision in the plantar aspect of the rat hind paw, leads to a remarkable reduction in paw withdrawal threshold to mechanical stimuli for several days, representing mechanical hyperalgesia [10]

Toward a unified biological hypothesis for the BDNF Val66Met-associated memory deficits in humans: a model of impaired dendritic mRNA trafficking