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Beyond the effects of the microglia, human and animal studies have shown that endotoxin-induced inflammation can also increase the neural responses in the anterior cingulate cortex and prefrontal regions, further impacting the processing of social and emotional information [218]

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TLR9 is localized in the endoplasmic reticulum prior to stimulation

Varkaris A, Katsiampoura A, Davis JS, Shah N, Lam M, Frias RL, Ivan C, Shimizu M, Morris J, Menter D, Overman M, Tran H, Heymach J, Chun YS, Vauthey JN, Calin G, Kopetz S

Nature 550 , 475480 (2017)