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Vincent van Gogh Psychologically tortured artist Van Gogh took comfort in pipe smoking and derived great peace from it during tumultuous times in his life, once calling his pipe in an 1875 letter "an old, trusty friend, and I imagine we'll never part again." Due to the many challenges in his lifetime he was largely poor and made little from his artwork he thought of smoking tobacco pipes as a means of consolation

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All must be clean and free from debris

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So, while the innate immune system bounces back quickly, the effects of smoking on the adaptive immune response persist