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Uncontrolled levels of oxidative stress may lead to inflammation, accelerate aging and facilitate the development of chronic conditions

Autophagy 12:142514283rd Bai Y, Meng L, Han L, Jia Y, Zhao Y, Gao H et al (2019) Lipid storage and lipophagy regulates ferroptosis

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doi: 10.1111/nyas.14468 5 ShenDYLiJHuPQiCYangH

SIRT1 suppresses AP-1 transcriptional activity and its downstream inflammatory mediator, cyclooxygenase 2 (COX2), by deacetylating PGC-1, thereby exerting anti-inflammatory effects [39]