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Although inheritance genetics plays an important role in the development of these diseases, the influence of environmental factors and lifestyle cannot be ignored (Table 1)
The dose-dependent effects of metformin on mitochondrial function underscore the importance of careful dosage management in clinical settings ( Furthermore, it is important to note that the effectiveness of metformin varies depending on the specific tissue and the dosage used ( 4 Unraveling the mechanisms behind metformin's antioxidant properties Metformin can modulate oxidative stress by inhibiting ROS production through pleiotropic actions, including AMPK modulation, mitochondrial complex I inhibition, and increased antioxidant enzyme activity
(2017) used functionalized MNPs to selectively stimulate the motor cortex in a rodent model
Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the global burden of disease study 2021
