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[7] [8] NAD+ and NADH are continuously recycled during redox reactions, but during other metabolic activities, they are absorbed by NAD+-dependent enzymes and may subsequently become depleted over time, increasing the risk of DNA damage, age-related illnesses, and mitochondrial malfunction

J Affect Disord (2010) 126:3269.10.1016/j.jad.2010.03.003 241 RosaARFreyBNAndreazzaACCeresrKMCunhaABQuevedoJet alIncreased serum glial cell line-derived neurotrophic factor immunocontent during manic and depressive episodes in individuals with bipolar disorder

Long-term safety data are lacking, and as with other peptides affecting tissue remodeling, theoretical concerns about promoting abnormal cell growth exist