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The approval is based on the Phase III JUPITER-02 study where Loqtorzi combined with chemotherapy significantly improved progression-free survival, reducing the risk of disease progression or death by 48% compared to chemo alone

Oxidative Stress Management : The demands of motherhood, coupled with hormonal changes, can lead to increased oxidative stress

An analysis based on elevated total cysteine (above the median) and low GSH-T (below the median) showed a similar result on GlyNAC efficacy in this subpopulation (medians, V2 = 817.7, V4 = 859.3 mg/L per %Ht, p -value = 0.015) (Supplementary Figure S3)

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Interestingly, ferroptosis induced by erastin or RSL3 can increase the expression of PTGS2 encoding COX2 [27]