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Half-life is influenced by drug distribution, drug metabolism, and drug excretion, each of which can be influenced by many factors such as age, use of concurrent medications, and presence of liver or renal disease

J Chromatogr B Biomed Appl 661:231235 Yang Y, Dieter MZ, Chen Y, Shertzer HG, Nebert DW, Dalton TP (2002) Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse

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The critical metric is not raw material cost per kg, but cost per unit of bioactive GSH effectively delivered to target tissues