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The acidosis correction persisted on subsequent testing over the remainder of her admission, indicating that the causative agent (acetaminophen) had been removed

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This may be due to the measurement of the combined peak of glutamate and glutamine or the need for more time or a steady-state concentration of NAC to increase the activity of metabotropic glutamate receptors and to downregulate synaptic glutamate release

Lee J, et al