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3.2.3 Reducing the Side Effects of TAM Although the use of TAM as an adjuvant endocrine therapy has effectively reduced the recurrence of ER+ breast patients and improved their survival rate, more and more studies have reported a series of side effects related to TAM that include hot flashes, night sweats, vaginal dryness, sleep, and emotional problems (Lorizio et al., 2012)

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Samples were then digested to single amino acids, acidified with heptofluorobutyric acid, chromatographed using a Shimadzu LC system equipped with an Eclipse XDB-C8 column (930990-906

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