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RipAY, a plant pathogen effector protein, exhibits Robust -glutamyl cyclotransferase activity when stimulated by eukaryotic thioredoxins

There are different forms of Hcy found in blood circulation, which consist of around 1% as free thiol, 7080% present and bound to plasma proteins, and the remaining 2030% present as forms homo/heterodimerized with other thiols [15]

It interacts with multiple pathways, including those regulating angiogenesis, collagen synthesis, and inflammation

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