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These results underscore the significance of spike-dependent CFTR reduction following authentic virus infection, and highlight the potential of cardiac glycosides as possible treatments to prevent SARS-CoV-2 infection, CFTR loss and the subsequent inflammatory response

Calcineurin is a transcription factor that is essential for the activation of nuclear factor of activated T-cells (NFAT), which is responsible for the production of pro-inflammatory cytokines, including IL-1, IL-2, IL-6, IL-4, and interferon (IFN)- (Pandey et al

These large molecules, even with the same mechanism of action in the form of inhibiting TNF alpha, may act differently, and they may have other adverse effects

The present study was supported by National Natural Science Foundation of China (grant nos

During the early 1990s, available evidence suggested that increased consumption of fruits and vegetables may be protective against cancer at some sites ( 2 )