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The laboratory of William Green, PhD, professor of neurobiology, made progress on this front when they discovered that varenicline gets trapped within cells acidic compartments called vesicles that contain nAChRs

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Brain imaging studies of adolescents who began smoking at a young age had markedly reduced activity in the prefrontal cortex of the brain, an area critical for a persons cognitive behavior and decision making, leading to increased sensitivity to other drugs and greater impulsivity