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A high level of MET amplification ( MET -to- CEP7 ratio of 5 on fluorescence in situ hybridization (FISH) or a 510-fold increase in MET copy number detected via NGS) has been used to distinguish tumours that are more likely to be MET-driven, based on the absence of co-occurring oncogenic drivers and response to MET-directed TKIs (highest in tumours with MET copy number 10) 112,114,118