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doi: 10.3389/fenvs.2015.00025 Received 18 January 2015 Accepted 13 March 2015 Published 31 March 2015 Volume 3 - 2015 Edited by Naser A

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Possible adverse effects may include: Injection site reactions : Redness, swelling, irritation, or discomfort Gastrointestinal symptoms : Nausea, vomiting, stomach cramps, or diarrhea Headaches or dizziness Allergic reactions : Rash, itching, shortness of breath, or facial swelling (rare) Increased heart rate or anxiety (typically temporary from B-vitamins) Fatigue or weakness if used improperly Elevated liver enzymes when taken in excess particularly with methionine or choline Insomnia if taken late in the day due to increased energy levels Who should avoid or use caution

Tagrisso is specifically indicated for people with exon 19 deletions or exon 21 mutations