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The area postrema (AP) in the brainstem is characterized by an open blood-brain barrier and has a high density of amylin receptors

"It also restored mobility to osteoarthritic mice and significantly reduced their pain." As a proof of principle that this might also work in humans, the researchers transferred human tissue into mice that were bred to not reject the tissue, and were able to show that human skeletal stem cells could be steered toward bone development but stopped at the cartilage stage

doi:10.1155/2020/6805354 Lee E, Padgett B