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In ALS models, SOD1 mutations do not markedly alter astrocytic baseline states but lower the threshold for reactivity, which sensitizes astrocytes to oxidative, glutamatergic and inflammatory stress and drives exaggerated reactive responses to otherwise moderate insults 80

k , PDK1-silenced HCT116 were re-expressed with PDK1 WT or K163R mutant, and cells were subjected to in vitro PIP3 binding assay

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On the other hand, much like in the healthy rats (Figure 2A), we demonstrated that immediately after saline or BPC 157 administration, there was consistent normal eye background and normal presentation of the retinal and choroidal blood vessels (IS and IB)