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Chronic Insomnia: In an open-label study involving patients with severe chronic insomnia, a treatment regimen of 10 intravenous injections of DSIP (25 nmol/kg) resulted in a normalization of sleep patterns that persisted for follow-up periods of 3 to 7 months.Crucially, the patients reported not just improved sleep duration, but improved daytime mood and performance, distinguishing DSIP from benzodiazepines which often cause daytime drowsiness and cognitive impairment

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90 At the same time, fatty acid oxidation (FAO) is ramped up through increased expression of carnitine palmitoyltransferase 1A (CPT1A) and other oxidation enzymes, which break down lipids to generate ATP and NADPH when Gln is scarce

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