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Abstract The microbiotagutbrain axis (MGBA) is increasingly recognized as a critical regulator of brain health, influencing both neurodevelopment and age-related neurological decline

In terms of pharmacological properties, DON and BPTES show moderate potency, poor metabolic stability, low water solubility, and limited selectivity for GLS, resulting in inferior antitumor efficacy compared to CB-839 (246, 247)

For topical or in vivo investigational use, concentrations of 0.05% to 0.1% (w/v) have been employed in wound-healing studies without reported adverse events

Despite the clear rationale for the use of antioxidants such as NAC as adjunct therapies in schizophrenia, clinical trials involving antioxidant administration to schizophrenic patients have led to equivocal results, with only a subset of trials finding statistically and clinically significant benefits [48,49,50]

& Kiecolt-Glaser, J