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High-dose oral B12 (10002000 micrograms daily) may be effective even in some malabsorption conditions through passive diffusion

This B12-intrinsic factor complex travels to the ileum, where it attaches to specific receptors and is absorbed into the bloodstream

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The affinity of the GHK tripeptide for copper is exceptionally high, and it is this complex that is believed to be the primary biologically active form

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