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501,502 Key recommendations: T1DM patients: Early and intensive glycemic control is recommended to prevent or delay the onset and progression of DPN and DAN

Neuronal loss can exacerbate the seizure severity (Zhang et al., 2002), and crucially, neuronal damage is directly associated with the initiation of epilepsy (Sayin et al., 2003)

In cases of chronic PTZ exposure, the production of free radicals significantly increases and causes oxidative stress damage (Samokhina and Samokhin, 2018)

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