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Before the development and synthesis of these peptides, research into tissue regeneration and skin remodeling relied largely on isolated growth factors and nonspecific biochemical agents

At follow-up, OED was significantly larger in the MIS-group compared to controls (median 0,51 versus 0,32cm, p = 0,01), while aPHO growth was significantly smaller in the MIS-group (median 0,2 versus 9,5mL, p = 0,05)

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