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In addition, the brain is rich in polyunsaturated fatty acids and a significant level of damage originates from lipid peroxidation and oxidative products such as carcinogenic 4-hydroxynonenal and potentially mutagenic malondialdehyde (Liu et al

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The idea was further validated by inhibiting glutathione synthesis by BSO where Sp administration caused GSH to increase by ~1.5 fold with concomitant reduction in GSSG (Fig

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