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Gallstone and metabolic dysfunction-associated gallstone disease (MAGD): conclusions and perspectives Gallstones affects about 20% of adults worldwide, and the gallbladder is the main target organ

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Birge RB, Boeltz S, Kumar S, Carlson J, Wanderley J, Calianese D, et al

Microbial metabolites like SCFA and Trp derivatives can activate AhR and its target genes, including IL-6, IL-22, prostaglandin G/H synthase 2 (PTGS2), vascular endothelial growth factor A (VEGFA), and cytochrome P450 1 A1 (CYP1 A1) in the intestine or liver

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