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Format: Nasal spray

A notable subset of patients with MCAS or specific genetic variants (such as CBS gene mutations) have impaired transsulfuration pathways or severe sulfur sensitivities

Three mechanistic explanations, not mutually exclusive: Signalling cascade persistence: BPC-157 activates VEGFR2 and FAK-paxillin pathways whose downstream effects (angiogenesis, fibroblast migration, collagen remodelling) unfold over days to weeks after initial receptor engagement

Ibrahim MA, Ashour OM, Ibrahim YF, El-Bitar HI, Gomaa W, Abdel-Rahim SR