leavitt & peirce tobacco refuses to be snuffed out by smoking laws LEAVITT & PEIRCE - Updated

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The first report of a smoking Englishman is of a sailor in Bristol in 1556, seen "emitting smoke from his nostrils"

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It should be noted that similar data collected on intact proteins using nominal resolution MALDI-TOF, where the detected ion is the + 1 m/z , would likely have insufficient resolution to detect the presence of single point mutant strains