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LPS (Lipopolysaccharides) has been demonstrated to considerably increase PGES-1 (prostaglandin E synthase-1) in microglia and by activating both constitutive and inducible COX (Cyclooxygenase) isoforms, PGE2 is released from astrocytes [8]

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To rule out the possibility that the observed Western blot signal for P-gp in Fig