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This is where a researcher's intuition, backed by solid data, comes into play

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Moreover, ebselen increased the expression of GPX2 and GPX4 in SGNs after peroxynitrite injury (Supplementary Figure 3), which is consistent with previous studies that ebselen can increase the expression of GPX2 or GPX4 in rat stomach (Xu et al., 2018), or cochlea ( With regard to how GPX1 influences the apoptotic outcome, the pieces of evidence indicate that GPX1 may influence several steps in apoptotic cascades via regulating oxidant accumulation

discussed glutathione synthesis as a key determinant in mitigating cuproptosis and disulfidptosis, two novel, metal-dependent cell death pathways exacerbated in sepsis

Moreover, chitosan-based microneedle transdermal delivery systems have attracted attention due to their painless application and high absorption efficiency (46)