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To differentiate between the potential involvement of these two consequences in H 2 O 2 -induced sensitization to TNF hepatotoxicity, we first exposed HepG2 cells to (BSO), a potent inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the glutathione synthesis pathway (Fig

However, no significant differences were observed in the SGRQ-C total score

10.1073/pnas.94.19.10367 [DOI] [PMC free article] [PubMed] [Google Scholar] 42.Mewis I, Schreiner M, Nguyen C, Krumbein A, Ulrichs C, Lohse M, et al

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