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Those KEAP1-binding competitors, such as p21 Cip1/WAF1 and BRCA1, were found interacting with NRF2 and thus block the association of KEAP1 with NRF2 [18, 19]

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10.1038/s41419-020-2481-5 45

This mechanism interferes with the synthesis of nucleotides necessary for cancer cell proliferation

CR has also increased NAD + levels in the brain and liver of mice, where it also activated sirtuin 1 (Sirt1) in both tissues.[13,14] In these studies, sirtuins increase because either more NAD + is available, less NADH is inhibiting the reaction, or both