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131,132 The brain is particularly sensitive to OS due to numerous variables, including rapid oxidative energy metabolism (a process through which ROS, which are harmful molecules, are constantly produced), high levels of unsaturated fatty acids (which are vulnerable to lipid peroxidation), and relatively low intrinsic antioxidant capability

M., Ridker, P

(2017) 12:e0179586

Circulation 102 , 4247 (2000)

2025), providing evidence that ascorbate and glutathione pools are redox-coupled in vivo and that the pathway can operate in different modes depending on flux and the relative capacities of these two reductases (Fig