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Mechanism mapping (Nature Communications, 2025) Identified the disordered p53 transactivation domain as the binding target, adding structural detail to the mechanism

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These washout periods can be anywhere from 3-60 days, depending on the specific glucocorticoid used and whether it was oral, intramuscular, or a local injection

Discussion In this study, a series of experiments were conducted to elucidate the desensitization mechanism of D2-like receptors, whose desensitization is not clearly explained by the conventional mechanism