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TT genotype is associated with increased risk of: Colorectal and lung cancers Unipolar depression Adult acute lymphoblastic leukemia Ischemic stroke Cleft lip/palate Down syndrome (especially when combined with methionine synthase reductase mutations) Interestingly, the 677T allele may confer reduced susceptibility to hepatitis B virus (HBV) infection in endemic regions

Environ Exp Bot 143:172184 Zhou B, Guo Z, Xing J, Huang B (2005) Nitric oxide is involved in abscisic acid-induced antioxidant activities in Stylosanthes guianensis

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For decades, the variety of hair loss treatments available ranged from ineffective and expensive, to painful with long recovery periods including medications, hair transplants, and even scalp micropigmentation tattoos