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Beyond gastrointestinal effects, clinical data and class-level evidence from licensed incretin agents (semaglutide, tirzepatide) have flagged concerns regarding: Heart rate elevation: Increases in resting heart rate are a recognised class effect of GLP-1 receptor agonists, documented in the SmPCs for semaglutide (Wegovy) and tirzepatide (Mounjaro)

In the decades that followed, research expanded to reveal that GHK is not merely a healing peptide but a master biological regulator capable of influencing thousands of genes related to tissue repair, anti-inflammation, collagen synthesis, and cellular regeneration