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The N-terminal domain of GSDMD (GSDMD-NT) has high affinity for acidic phospholipids, phosphatidylserine, and cardiolipin, which are rich in the inner leaflet of the plasma membrane and in the mitochondrial membrane (80)

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In addition, we will discuss the advantages of combining ITC and Se to benefit from their complementary mechanisms of action to potentially prevent the accumulation of alterations during neoplastic transformation that lead to uncontrolled cell growth and loss of genomic stability

Expect pain levels of 2-5/10 with an initial flare in 60-70% of patients