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TB-500 is based on a part of TB4, so it should, in theory, have a similar safety profile, but studies specifically analyzing its safety still need to be conducted

As a triple receptor agonist targeting GIP, GLP-1, and glucagon pathways simultaneously, it differs structurally and mechanistically from earlier weight management peptides

Stegeman I, Eikelboom RH, Smit AL, et al

The anti-inflammatory and anti-oxidant mechanisms of the Keap1/Nrf2/ARE signaling pathway in chronic diseases

It is well established that iron overload and more generally ferroptosis can trigger macrophage polarization, increasing M1-like markers such as IL-6, IL-1, and TNF, while decreasing M2-like markers [25, 26]