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DCE-MRI BBB permeability maps were created using the slope of contrast agent concentration in each voxel over time, calculated using a linear fit model as described previously 70,71,72

The cells were then collected and washed, followed by quantification of cellular levels of Cystine-FITC by flow cytometry analysis

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The induction of the antimicrobial peptide gene expression is mostly initiated by binding of transcription factors like NF- B, AP-1, and STAT3 [26] due to activation of Toll-like receptors by microbial antigens or initiated by cytokines [27]

The agency will review DSIP for opioid withdrawal, chronic insomnia, and narcolepsy at its July 2026 Pharmacy Compounding Advisory Committee meeting