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By leveraging the multifunctional properties of hydrogelsmechanical support, controlled drug delivery, and microenvironmental modulationit is possible to address the primary limitations of conventional cervical cancer brachytherapy, including dose heterogeneity, hypoxia-driven radioresistance, and immunosuppressive tumor microenvironments [21, 162]

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doi:10.1146/annurev.arplant.49.1.249

In addition, the physical and the chemical properties of the nanomaterials can be controlled exogenously or endogenously